ESF Research Conferences

Conference Opening and Welcome Message from the Chair

Session I : Theory & Computation

Chair: Zhiping Weng, University of Massachusetts, Worcester, MA, US

Rebecca Wade, Heidelberg Institute for Theoretical Studies, Heidelberg, DE

What determines diffusion, association and oligomerization in concentrated
protein solutions?

09:05-09:35

Sarah Teichmann, MRC Laboratory for Molecular Biology, Cambridge, UK

Evolution & Dynamics of Protein Complexes

Ora Schueler-Furman, Hebrew University of Jerusalem, IL

Session II: Membrane protein complexes

Chair: Jacob Piehler, University of Osnabrück, DE

Colin Kleanthous, University of Oxford, UK

Assembly of an outer membrane toxin translocon

Lunch

Session III: Kinetics & Thermodynamics

Chair: Colin Kleanthous, University of Oxford, UK

Zhiping Weng, University of Massachusetts, Worcester, MA, US

Protein docking and design

Gideon Schreiber, Weizmann Institute of Science, Rehovot, IL

Formation of protein-complexes in crowded environments: From in vitro to in vivo

Session IV: Evolution and design

Chair: Patrick Aloy, Institute for Research in Biomedicine, Barcelona, ES

08:30-09:00

Sarel Fleishmann, Weizmann Institute of Science, Rehovot, IL

Computational design of novel protein-protein interactions: protein-based inhibitors and computational antibody design

Sachdev Sidhu, University of Toronto, CA

From antibodies to synthetic proteins

Session V: Signalling complexes

Chair: Sachdev Sidhu, University of Toronto, CA

Stefan Raunser, Max Planck Institute of Molecular Physiology, Dortmund, DE

Life and Death of a Bug: A Structural View

Jacob Piehler, University of Osnabrück, DE

Assembly and dynamics of cytokine-receptor signalling complexes

12:10-12:30

Session VI: Networks

Chair: Rebecca Wade, Heidelberg Institute for Theoretical Studies, Heidelberg, DE

Ulrich Stelzl, Max Planck Institute Molecular Genetics, Berlin, DE

Coordination of post-translational modifications in human protein interaction networks

Shoshana Wodak, University of Toronto, CA

Protein-protein interaction data: the good, the bias, and the ugly

Patrick Aloy, Institute for Research in Biomedicine, Barcelona, ES

A top-down systems biology approach to novel therapeutic strategies  

Session VII: Structural Approaches

Chair: Peter Wright, Scripps Research Institute, La Jolla, CA, US   

17:35-17:55

Session VIII: Intrinsically unstructured protein complexes

Chair: Lynne Regan, Yale University, Newhaven, CT, US

Peter Wright, Scripps Research Institute, La Jolla, CA, US

Functional interactions of intrinsically disordered proteins in signaling networks

Monika Fuxreiter, University of Debrecen, HU

Fuzziness: a new view on protein interactions

Session IV: Large multi-protein complexes

Chair: Gideon Schreiber, Weizmann Institute of Science, Rehovot, IL

Bernd Bukau, Ruprecht-Karls University, Heidelberg, DE

Mechanisms of de novo folding and quality control of proteins

Gabriel Waksman, Birkbeck & University College London, UK

Transport through membranes by a bacterial secretion nano machine

12:10-12:30

Session X: Transient Interactions

Chair: Peter Crowley, National University of Ireland, Galway, IR   

Brian Hoffman, Northwestern University, Evanston, IL, US

Symmetry Breaking and Making in Electron Transfer Across a Re-Designed Protein-Protein Interface

Marcellus Ubbink, University of Leiden, NL

The nature of the encounter complex: Photosynthetic electron transfer proteins as an example

Session XI: Emerging techniques

Chair: Shoshana Wodak, University of Toronto, CA

11:00-11:30

Peter Crowley, National University of Ireland, Galway, IR

Protein surface recognition by calixarenes - assembly and camouflage 

Despoina Mavridou, University of Oxford, UK

Concerted protein-protein interactions drive heme delivery in cytochrome c assembly

Session XII: Protein-protein interactions in disease and drug development

Chair: Ulrich Stelzl, Max Planck Institute Molecular Genetics, Berlin, DE

Lynne Regan, Yale University, Newhaven, CT, USA

Creating novel protein-protein interactions by selection and design

Yuan Chen, City of Hope, Duarte, CA, US