ESF-EMBO Symposium
Molecular Perspectives on Protein-Protein Interactions
14-19 November 2010
Preliminary Programme |
| Sunday 14 November | |
| 16:00 - 19:00 | Registration at ESF desk |
19:30 - 20:30 | Dinner |
| 20:30 - 20:40 | Opening Remarks |
| 20:40 - 21:30 | Peter Wright, The Scripps Research Institute, US Promiscuous liaisons: functional interactions of intrinsically disordered proteins in signaling networks |
| 21:30 | Welcome Drink |
| Monday 15 November | |
| Session 1 – Theory & Computation | |
| 8:30 - 9:05 | Rebecca Wade, EML, DE Simulation of protein association and binding |
| 9:05 - 9:40 | Tanja Kortemme, UCSF, US |
| 9:40 - 10:00 | Domene Carmen, University of Oxford, UK Chemical basis for the selectivity of the von Hippel-Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha |
| 10:00 - 10:20 | Attila Gursoy, Koc University, TR Large scale construction of three-dimensional protein-protein complex structures |
| 10:20 -10:50 | Coffee Break |
| Session 2 – Kinetics & Thermodynamics | |
| 10:50 -11:25 | Amy Keating, MIT, US Elucidating specificity determinants in Bcl-2 family protein-peptide interactions |
| 11:25 - 11:45 | Ora Schueler-Furman, Hebrew University, IL Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions? |
| 11:45 -12:05 | Adrien S. J. Melquiond, Utrecht University, NL The butterfly effect in protein-protein interactions |
| 12:05 - 12:25 | Julia Shifman, Hebrew University, IL Can we beat evolution? Improving affinity and specificity of a pM protein-protein interaction |
| 12:25 - 14:20 | Lunch and break |
| 14:20 -14:55 | Gideon Schreiber, Weizmann Institute, IL Protein association in solution and in the crowd |
| 14:55 - 15:30 | Marcellus Ubbink, Leiden University, NL Transient complexes of electron transfer proteins |
| 15:30 -15:50 | Brian Baker, University of Notre Dame, US Reducing entropic penalties as a natural strategy for T cell receptor selection in cellular immune responses |
| 15:50 - 16:20 | Coffee Break |
| 16:20 - 16:55 | Lucia Banci, University of Florence, IT Transient protein complexes in protein folding and metal transfer |
| 16:55 - 17:30 | Anthony Kossiakoff, University of Chicago, US Dynamics and binding: An inseparable partnership |
| 17:30 - 17:50 | Xavier Salvatella, IRB, Barcelona, ES Motions in macromolecules play key roles in biological functions ranging from enzyme catalysis to molecular recognition |
| 17:50 - 18:10 | Abel Garcia-Pino, Vrije University Brussel, BE Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity |
| 19:00 - 20:30 | Dinner |
| 20:30 - 22:30 | Poster session (Drinks offered by the sponsors) |
| 19:00 - 20:30 | Dinner |
| 20:30 - 22:30 | Poster Session (Drinks offered by the Sponsors) |
| Tuesday 16 November | |
| Session 3 – Protein-protein interactions in disease and drug development | |
| 8:30 - 9:05 | Arne Skerra, TU, DE Towards novel biopharmaceuticals via protein design: Anticalins and PASylation |
| 9:05 - 9:40 | Leo James, MRC, UK HIV and the Red Queen |
| 9:40 - 10:00 | C. Ronald Geyer, University of Saskatchewan, CA Genetic Selection of “Lariat” Peptides for Characterizing Protein Function and Confirmation |
| 10:00 - 10:20 | Julia Schanda, Institute for Medical Research, DE Peptide and small molecule inhibitors to disassemble the AML1/ETO tetramer in acute myeloid leukemia (AML) |
| 10:20 -10:50 | Coffee break and group picture |
| Session 4 – Protein interaction networks | |
| 10:50 - 11:25 | Stephen Michnick, University of Montreal, CA |
| 11:25 - 12:00 | Sachdev Sidhu, University of Toronto, CA Engineered proteins for perturbation of protein-protein interactions |
| 12:00 -12:35 | Patrick Aloy, IRB, ES A network biology approach to complex diseases |
| 12:35 - 12:55 | Jason Moffat, University of Toronto, CA A pooled genetic screening approach for spatially driven protein interactions in mammalian cells |
| 12:55 - 14:55 | Lunch and break |
| Session 5 – Membrane protein complexes | |
| 14:55 - 15:30 | Colin Kleanthous University of York, UK Colicin translocon assembly at the bacterial cell surface |
| 15:30 - 16:05 | Igor Stagljar, University of Toronto, CA Protein Interaction Networks Regulating Cell Signaling in Cancer |
| 16:05 - 16:25 | Georgios Gouridis, IMBB-FORTH and University of Crete, GR Molecular mechanism of protein translocase activation |
| 16:25 - 16:55 | Coffee Break |
| 16:55 - 17:15 | Neil Barclay, Oxford University, UK Global Identification of Labile Disulfide Bonds in Membrane Proteins and Regulation of Function |
| 17:15 -17:35 | Despoina Mavridou, University of Oxford, UK Oxidation-state-dependent protein-protein interactions in disulfide cascades |
| 17:35 - 17:55 | Ylva Ivarsson, K.U. Leuven, BE Integration of lipid and peptide binding by PDZ domains |
| 17:55 - 18:15 | Dimitrios Stamou, University of Copenhagen, DK |
| 19:00 - 20:30 | Dinner |
| 20:30 -22:30 | Poster Session (Drinks offered by the Sponsors) |
| Wednesday 17 November | |
| Session 6 – Emerging and single molecule techniques | |
| 8:30 - 9:05 | Joseph Puglisi, Stanford University, US Dynamics of Translation |
| 9:05 - 9:40 | Claus Seidel, University of Düsseldorf, DE Conformational dynamics and biomolecular interactions studied by multiparameter fluorescence spectroscopy |
| 9:40 - 10:00 | Anders Gunnarsson, Chalmers University, SE Probing Molecular Recognition on the Single Molecule Level |
| 10:00 - 10:20 | Ignacio Casuso, Institute Curie, FR Experimental evidence for membrane-mediated protein-protein interaction |
| 10:20 -10:40 | Klaus Gerwert, Ruhr-University Bochum, DE The Ras interaction network monitored by tr(time-resolved) FTIR spectroscopy |
| 10:40 - 11:10 | Coffee Break |
| Session 7 – Intrinsically unstructured protein complexes | |
| 11:10 -11:45 | Madan Babu Mohan, MRC, Cambridge, UK Intrinsically Disordered Proteins: Regulation and Disease |
| 11:45 - 12:05 | Carlos Walter Bertoncini, IRB, Barcelona, ES Diverse structural features in protein complexes of the intrinsically disordered protein α-synuclein |
| 12:05 - 12:25 | Flemming Martin Poulsen, University of Copenhagen, DK Conformational selection in the molten globule state and cooperative formation of native-like tertiary contacts in the ensemble of unfolded states of helical proteins |
| 12:25 - 12:45 | Dana Reichmann, University of Michigan, US How Do Intrinsically Unfolded Chaperones Work? |
| 12:45 -14:00 | Lunch |
| 14:00 - 19:00 | Excursion to Girona |
| 19:00 | Dinner and free evening |
| Thursday 18 November | |
| Session 8 – Signalling complexes | |
| 8:30 - 9:05 | Jacob Piehler, University of Osnabrueck, DE Diffusion and interaction in type I interferon signalling |
| 9:05 - 9:40 | Luis Serrano, Centre for Genomic Regulation, ES Signal transduction networks analyzed by integrating interactions, structures, concentrations and microscopy |
| 9:40 - 10:00 | Roland Brock, University Nijmegen, NL Quantitative Analyses of Protein Complexes in Early T Cell Signaling |
| 10:00 - 10:20 | Mickey Kosloff, Duke University Medical Center, US Deciphering the design principles of selective G-protein inactivation by RGS proteins |
| 10:20 - 10:50 | Coffee break |
| Session 9 – Evolution and design | |
| 10:50 - 11:25 | Luhua Lai, University of Beijing, CN Testing Different Strategies for Novel Protein Interaction Pair Design |
| 11:25 - 11:45 | Eric Sundberg, Boston Biomedical Research Institute, US |
| 11:45 - 12:05 | Natasa Przulj, Imperial College London, UK Protein-Protein Interaction Network Topology Uncovers Evolution, Disease, and Gene Functions |
| 12:05 - 12:25 | Katja Arndt, University of Potsdam, DE Photo-Switchable Peptides Targeting Extended Protein Interaction Surfaces |
| 12:25 - 14:25 | Lunch and Break |
| Session 10 - Multi-protein complexes | |
| 14:25 - 15:00 | Michal Sharon, Weizmann Institute, IL Characterizing ligand binding to protein complexes |
| 15:00 - 15:20 | Helena Barysz, University of Edinburgh, UK Cross-linking/mass spectrometry to model multi-protein complexes |
| 15:20 - 15:40 | Maria Francesca Mossuto, IRB, Barcelona, ES Intramolecular disulfide bonds steer amyloidogenic states of proteins towards the formation of ordered and stable fibrils |
| 15:40 -16:00 | Dierk Niessing, Helmholtz Zentrum Muenchen, DE Mechanistic insights into mRNA transport by vitro reconstitution of the core-transport complex |
| 16:00 - 16:30 | Coffee Break |
| 16:30 - 17:05 | Marius Clore, NIH, US Hybrid structure determiantion methods, paramagnetic relaxation and differential relaxation |
| 17:05 - 17:25 | Paul Rösch, University of Bayreuth, DE Nus-Factors: Conformational Switches of Bacterial Transcription |
| 17:25 - 17:45 | Kristian M. Müller, University of Freiburg, DE Development and Use of a Bacterial Screening System for Dimeric, Trimeric and Tetameric Protein-Protein Interactions |
| 17:45 - 18:05 | Frederic Cazals, INRIA Sophia-Antipolis, FR Assessing the Stability of Protein Complexes within Large Assemblies |
| 18:05 - 18:30 | Forward look session |
| 19:00 | Get together drink and Conference dinner |
| Friday 19 November | |
| 8:00 | Breakfast and Departure |
| List of accepted posters - Poster prizes sponsored by EMBO, one-year subscription to EMBO reports will be awarded at the end of the conference. | |
| Andersson Fredrik | Real-time characterization of protein-protein interactions using QCM-D |
| Apelbaum Amir | Understanding Type I Interferons-induced Cell Death |
| Arndt Katja M. | Photo-Switchable Peptides Targeting Extended Protein Interaction Surfaces |
| Barysz Helena | Reporter Ion Signature for Cross-linked Peptides |
| Beermann Sandra | Cellular RNA helicase DDX3 as potential antiviral target for HIV |
| Benderska Natalya | Identification and characterization of a new DAPK interaction complex during TNF-induced apoptosis in colon cancer cells |
| Brignone Maria Stefania | The yeast two-hybrid system assay unravels the interaction between the beta 1 subunit of the Na,K-ATPase pump and the Megalencephalic Leucoencephalopathy with subcortical Cyst protein 1 (MLC1) in brain |
| Bustos Susan | Protein 4.2 Interaction with Hereditary Spherocytosis Mutants of the Cytoplasmic Domain of Human Anion Exchanger 1 |
| Caffrey Daniel | Evolution of Protein-Protein Interaction Sites Following Gene Duplication |
| Capitani Guido | An evolutionary approach for distinguishing biologically relevant interfaces from crystal contacts |
| Cassels Eoin | Order-disorder signalling in the Tol complex of Gram-negative bacteria |
| Casuso Ignacio | High Speed AFM study pf the membrane-mediated protein-protein interaction |
| Chakravarty Devlina | An analysis of the structural changes during protein-protein interaction |
| Chernov Konstantin | Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP |
| Chopra Nikita | Modeling of the protein-protein interactions of a Bacillus anthracis Toxin Antitoxin Module: Evidence from deletion mutants and structure function studies |
| Cohavi Ori | A quantitative, real-time assessment of binding of peptides to gold surfaces |
| Das Madhurima | Inter-subunit orientations in protein-protein complexes are electrostatically biased |
| Der Bryan | Designing metal-bridged protein-protein interactions: computational modeling and experimental investigation |
| Dey Sucharita | Clustering of conserved residues and propensities in the identification of protein-DNA interfaces |
| Dreyfus Tom | Assessing the Stability of Protein Complexes within Large Assemblies |
| Etoc Fred | Toward a magnetic control of cell polarity |
| Falk Sebastian | cpSRP43 is a highly specific membrane protein chaperone and targeting factor |
| Fedorova Anna | The Development of Peptide-based Tools for the Analysis of Angiogenesis |
| Green Victoria | Structural Studies of the BLM Dissolvasome |
| Grossman Moran | The interplay between enzyme and water functional motions during protein-protein interactions and catalysis |
| Guharoy Mainak | Side-chain torsion angle distributions in unbound proteins and in protein-protein interfaces |
| Gurumurthy Rajendra Kumar | Chlamydia trachomatis recruits RAF1 to the inclusion via interaction with 14-3-3β and induces RAS/RAF independent MEK/ERK signaling |
| Halff Els | Structural and functional analysis of immune receptors and their interaction partners |
| Hawkins John Charles | Structure-based Methods for Improving Protein Binding Prediction |
| Helft Laura | Conservation Mapping to Identify Leucine-Rich Repeat Functional Sites |
| Hellmann Nadja | General properties of cooperative and hierarchical interactions |
| Hengstenberg Carola Sophie | Structural and dynamic features of the immuno-active GTPase hGBP1 - A single molecule study |
| Inbar Yuval | Protein structure modeling and evaluation based on a 4-distance description of side-chain interactions |
| Kapri-Pardes Einat | Stabilization of the alpha2 isoform of Na,K-ATPase by mutations in trans-membrane segments |
| Karaca Ezgi | Divide and conquer: a multi-body HADDOCKing approach to deal with large conformational changes in the modeling of biomolecular complexes |
| Keskin Ozlem | Large scale construction of three-dimensional protein-protein complex structures in human proteome |
| Koch Joaquim | BAT3-dependent recognition of tumor cells by the NKp30 receptor of natural killer cells |
| Kock Klaus | Protein-protein interaction in crowding solutions |
| Kolbusz Magdalena Anna | Membrane Topology of Small Multidrug Resistance transporters and the Positive-Inside Rule |
| Krishna Kumar Kaavya | Stealing Haem from Haemoglobin |
| Krueger Sabine | Identification of novel interaction partners of human cathepsin X in gastric cancer |
| Lanciotti Angela | MALDI-TOF analysis for the identification of molecular interactors of MLC1, a membrane protein of unknown function, involved in Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC) |
| Levin Doron | Reduced interferon receptor levels promote a shift in cellular responsivness to type I interferons |
| Lewis Steven | Anchored Design of Protein-Protein Interfaces |
| Liron Tamar | Rational design of a novel Erythropoietin-Receptor peptide antagonist |
| Lisse Domenik | Selective targeting of monofunctional nanoparticles to proteins for probing individual protein-protein interactions in living cells |
| London Nir | Mapping the “Farnesylome” - Structure-based Prediction of Farnesyl Transferase Targets |
| Macchi Francesca | Mechanical stress induces polymorphism in glucagon fibrils |
| Maksimenko Oksana | Revision to GAGA factor: new and well known activities |
| Malod-Dognin Noël | Generic framework for Protein Structure Comparison with Application to the Contact Map Overlap Maximisation Problem and to the Alignment of Internal Distances |
| Mazini Ribeiro Natalia | New endogenous peptide: identification, characterization and potential functions in protein-protein interactions |
| Mereuta Loredana | The role played by lipids packing upon the mechanisms of transmembrane translocation of alpha-helical antimicrobial peptides |
| Motackova Veronika | NMR as a tool for studies of (partially) disordered proteins and their interactions |
| Ohse Nadine | Multiple interactions of Rassf5 in the apoptotic pathway of Ras |
| Ozkirimli Elif | Beta-Lactamase Ligand Binding: A Comparative Study |
| Pál Gábor | Selective blocking of the lectin pathway of the complement system with phage display evolved peptide inhibitors |
| Papadakos Grigorios | Exploring the kinetics of competitive TolB recruitment by the intrinsically unstructured region of ColE9 |
| Patrone Marco | The complex fusion machinery of Human cytomegalovirus |
| Perdomo Doranda | Biochemical analysis of the lysine and glutamic acid rich protein KERP1, a virulence factor in Entamoeba histolytica |
| Phillip Yael | Common Crowding Agents Have Only a Small Effect on Protein-Protein Interactions |
| Pink Anne | Soluble CD44 Interacts with Intermediate Filament Protein Vimentin on Endothelial Cell Surface |
| Pinney John | Protein interaction network properties in the presence of ascertainment bias |
| Podoplelova Yulia | Ligand recognition and conformational changes of the type I interferon receptor subunit IFNAR1 |
| Pons Perez Carles | Structural characterization of protein-protein complexes by integrating computational docking with small-angle scattering data |
| Poorgholi Belverdi Mohammad | Towards the BMP Receptor Interactome |
| Prévost Chantal | Accounting for interface remodeling during macromolecular docking |
| Ramirez-Sanchez Israel | Epicatechin induces formation of HSP90/AKT/sGC/eNOS complex in human coronary artery endotelial cells under Ca2+- free conditions |
| Raveh Barak | Sub-angstrom modeling of complexes between flexible peptides and globular proteins |
| Reingewertz Tali Haviv | The C-Terminal Domain of the HIV-1 Vif Protein is Natively Unfolded in its Unbound State |
| Rezabkova Lenka | Biophysical characterization of RGS3/14-3-3 protein complex |
| Robert Charles | Side-chain torsion angle distributions in unbound proteins and in protein-protein interfaces |
| Rogov Vladimir | NMR-compatible expression tag provides new perspectives in the study of proteins and their interactions |
| Roucourt Bart | Dissecting the role of heparanase in tumor angiogenesis and metastasis |
| Russo Lilian | Intracellular peptides can be natural regulators of protein interactions |
| Sacquin-Mora Sophie | Identification of protein interaction partners and protein-protein interaction sites |
| Samsonov Sergey | Graphical analysis, classification and inference of protein-protein, protein-nucleic acids and protein-saccharides interactions beyond family level |
| Santos Schröter Filipa | Finding PIN1 interacting protein using the rURA-based Y2H membrane split ubiquitin system |
| Schwarzinger Stephan | Fast Mapping of biomolecular interfaces by random spin labeling (RSL) |
| Smith Colin | Prediction of PDZ-peptide specificity using structure-based flexible backbone modeling |
| Stemberk Vaclav | Interactions of Staphylococcus aureus with Fibrinogen and Fibronectin |
| Stranges Peter Benjamin | Computational design of novel Beta-strand mediated protein-protein interfaces |
| Sushko Anna | AFM Investigation of Early Stages of Fibrinogen Association |
| Teale William | An investigation into the PIN1 complex of Arabidopsis thaliana |
| Teller Anne | Identification of novel interaction partners of human cathepsin X in gastric cancer |
| Topping Ryan | Probabilistic reconstruction of the history of the proteasome |
| Trautmann Susanne | MAPK-signaling – quantification of protein interactions in vivo using FCCS |
| Velvarska Hana | Structural and Functional Studies on Myosin Type V- Dependent Organelle |
| Weber Axel | Inhibition of STAT3 & STAT5 functions with multifunctional peptide aptamers |
| Wehner Mark | Biochemical characterization of the human guanylate-binding protein 5 and a tumor-specific C-terminally truncated splice variant reveal similar enzymatic properties |
| Wikstrom Mats | Interaction between the streptococcal protein SIC and the human chemokine MIG/CXCL9 |
| Wojdyla Justyna Aleksandra | High-affinity protein-protein interaction: cognate and non-cognate colicin DNase-immunity protein complexes |
| Zhang Changsheng | SFDOCK:protein-protein docking by step-wise potential force-field |
| Zidek Lukas | Molecular and thermodynamic characterization of interactions of histidine kinase CKI1 receiver domain with AHP proteins in Arabidopsis thaliana |
| Zimmermann Pascale | Crystals reveal peptide and phosphoinositide coincident detection by Syntenin PDZ2 domain |
Partnership
This conference is organised by the European Science Foundation (ESF) in partnership with the European Molecular Biology Organization (EMBO).
With Support from
