This ESF-EMBO Conference aims to create a timely forum for multi-disciplinary discussions of recent developments in the ionising radiation effects on integrated living systems, from molecular to tissular scales, bringing together physicists, chemists, biochemists, biologists, genetics experts as well as physicians with a common interest in using different radiation sources and advanced techniques to explore transdisciplinary aspects of modern radiation biology and related biomedical applications. Deeply understanding the basic mechanisms of radiation damage in vitro and on living cells, starting from the early radical and molecular processes to mutagenic DNA lesions, cell signalling, genomic instability, apoptosis, microenvironment and Bystander effects, radio sensitivity should have in the near future many practical consequences like the customization of radiation therapy or radioprotection protocols. In this context, spatio-temporal radiation biology represents a newly emerging interdisciplinary field of studies driven nowadays in strong synergy with the most recent progresses of molecular biology, genomics and proteomics, biomarker detections, X-ray synchrotron micro-imaging, microbeams, pulsed relativistic particle sources, selective targeting radiopharmaceutical, advanced radiation therapies.
This ESF-EMBO symposium will gather together actors from the academic, applied and medical domains as well as private companies and clinicians, to take advantage of the high research quality and technological environment developed in a European and international context. The programme will address a number of highly topical aspects of spatio-temporal radiation biology, evolving over several orders of magnitude, typically from femtosecond and sub-micrometric scales.
Scientific sessions will focus on:
- Session 1 – Molecular and sub-cellular imaging of radiation effects Spatio-temporal organization of molecular damages – Real-time molecular organization Sub-cellular redistribution of molecular processes
- Session 2 – Prethermal and thermal radiation processes Short-time course events and collective effects – Molecular dynamics of elementary processes - Spatial distribution of molecular damages in tracks
- Session 3 – Induction, amplification of damages Spatial induction of molecular damages – Chromosomal aberrations and gene amplification – Radionuclides – Targeting radiopharmaceuticals – Modulation of radiosensitivity
- Session 4 – Microbeam radiation Microbeam irradiation and unique cell – Microbeam dosimetry for radiation therapy
- Session 5 – Microenvironment and radiation responses Nanodosimetry - Non targeted radiation effects and carcinogenesis – 2 and 3D Bystander response – Real-time nucleation
- Session 6 – Cellular imaging for radiation biology X ray micro-imaging – Cellular organization and molecular repair – Chromatin remodeling
- Session 7 – Innovation approaches for radiotherapies Development of hadrontherapy – Pulsed relativistic particle sources – Simulations for clinical treatments.
The conference will be organized around transdisciplinary advances communicated in invited oral presentations and selected short talks. The synergy between participating scientists will be encouraged during flash poster presentations, and poster sessions. A poster prize sponsored by EMBO will be awarded at the end of the conference. A forward look plenary discussion will be planned for identifying some innovating developments. Some grants will be available for invited speakers and young researchers.