326 Final Programme

17:00 - 19:00

Registration at ESF Desk

19:00

Welcome Drink

19:30

Dinner

Welcome Address

08:30 -  09:00

Michelle Peckham University of Leeds, UK
Pilar Perez - Consejo Superior de Investigaciones Científicas, ES

Session 1: Myosin Structure and Function

09:00 - 09:30

Michelle Peckham University of Leeds, UK
Diversity in the myosin superfamily

09:30 - 10:00

Anne Houdusse - Institut Curie, FR
How myosin VI moves - answers from structural studies of this reverse motor

10:00 - 10:15

Jim Sellers - NIH, US
Regulation of Drosophila myosin-7a by a binding partner
(short talk)

10:15 - 10:30

Margaret Titus - University of Minnesota, US
Chemotactic signalling requires a MyTH/FERM myosin
(short talk)

10:30 - 11:00

Coffee break

11:00 - 11:30

Claudia Veigel - University of Munich, DE
How single myosin motors work under load

11:30 - 12:00

Justin Molloy - NIMR, UK
How actin and myosin are guided by weak forces

12:00 - 12:15

Dan Mulvihill - University of Kent, UK
The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast
(short talk)

12:15 - 12:30

Matthew Lord - University of Vermont, US
Differential regulation of fission yeast myosins via changes in the actin track
(short talk)

12:30

Lunch

Session 2: Actin Dynamics and Organisation I

15:30 - 16:00

Coffee Break

16:00 - 16:30

Marie-France Carlier - CNRS, FR
Actin Dynamics 

16:30 - 16:45

Jonathan Terman - University of Texas, US
The multi-domain redox enzyme MICAL is a novel F-actin disassembly factor that directly regulates the actin cytoskeleton in response to extracellular guidance cues
(short talk)  

16:45 - 17:00

Thomas Iskratsch - King's College London, UK
Formin follows function: a muscle specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
(short talk) 

17:00 - 17:30

Jan Faix - University of Hannover, DE
Cofilin and fascin cooperate in the disassembly of filopodia

17:30 - 17:45

Jennifer Gallop - Harvard Medical School, US
Self-assembly of filopodia-like structures on supported lipid bilayers
(short talk)

17:45 - 18:00

Metello Innocenti - Netherlands Cancer Institute, NL
Role of mDia2 in filopodium formation as revealed by biochemistry   
(short talk)

18:00 - 18:15

Sawako Yamashiro - Scripps Research Institute, US
Mammalian tropomodulins nucleate actin polymerization via their actin monomer-binding and filament pointed end-capping activities
(short talk)

18:15 - 18:30

Peter Gunning - University of New South Wales, AU
Tropomyosin Tn5NM1/2 regulates cell proliferation
(short talk)

19:00

Dinner

20:30 - 22:00

Poster Session I

Session 3: Actin Dynamics and Organisation II

09:00 – 09:30

Klemens Rottner - Helmholtz Centre for Infection Research, DE
Analysis of Arp2/3-complex function in protrusion

09:30 - 09:45

John Heuser - Washington University, US
Revisiting the ultrastructure of the cytoskeleton
(short talk)  

09:45 - 10:00

Rhoda Hawkins - University of Bristol, UK
Rebuilding cytoskeletal roads: Active-transport-induced polarisation of cells
(short talk) 

10:00 – 10:15

Keren Kinneret - Technion Israel Institute of Technology, IL
Actin disassembly “clock" determines lamellipodial morphology
(short talk) 

10:15 - 10:30

Florian Huber - University of Leipzig, DE
Actin network formation within cell-sized droplets: from star-like clusters to ladder-like stripes
(short talk)   

10:30 - 10:45

Group Photo

10:45 - 11:15

Coffee break

11:15 - 11:45

Anne Ridley - King's College London, UK
Regulation of cytoskeletal dynamics by Rho GTPases

11:45 - 12:15

Pekka Lappalainen - Institute of Biotechnology Helsinki, FI
Assembly and dynamics of actin stress fibers

12:15 - 12:30

Evelyne Bloch-Gallego - Institut Cochin, FR
Role of netrin-1, its receptor DCC, tubulin modifications and RhoGTPases in the oriented migration of hindbrain neurons
(short talk)

12:30

Lunch

Session 4: Forces and Cell Adhesion in Biology

15:30 - 16:00

Coffee break

16:00 - 16:30

Pierre-François Lenne - Institut de Biologie du Développement de Marseille Luminy, FR
Force generation and transmission during tissue morphogenesis

16:30 - 16:45

Antonio Schepis - Stanford University, US
Alpha-E-catenin is required for gastrulation cell movement in zebrafish
(short talk)   

16:45 - 17:00

Di Jiang - University of Bergen, NO

Regulation of actin dynamics by actin binding proteins in actomyosin contractile ring that drives notochord cell elongation

17:00 - 17:15

Bo Dong - University of Bergen, NO

N-WASP-dependent actin dynamics serves as a switch for extracellular lumen or intracellular vacuole formation during ascidian notochord tubulogenesis   

17:15 - 17:30

Sasha Bershadsky - Weizmann Institute, IL
Focal Adhesions as mechanosensors
(short talk)

17:30 - 17:45

Ronen Zaidel-Bar - Mechanobiology Institute, SG
Regulation of cell-cell adhesion and the cytoskeleton during C. elegans morphogenesis
(short talk)

17:45 - 18:00

Pere Roca-Cusachs - Columbia University, US
Depletion of alpha-actinin reveals two mechanotransduction steps in cell adhesion
(short talk)

19:00

Dinner

20:30 - 22:00

Poster Session II

Session 5: Force Generation and Cellular Transport

09:00 - 09:30

Mathias Rief - Ludwigs-Maximilians-Universität München, DE
Single molecule mechanics of cytoskeletal proteins

09:30 - 10:00

Christoph Schmidt - Georg-August-Universität, DE
Mechanical communication between cells and environment  

10:00 - 10:15

Julien Husson - Insitut Curie, FR
Stiffness-adaptave force generation by primary T cell on surrogate APC: role of the TCR-CD3 complex and LFA1 integrin
(short talk)

10:15 - 10:30

Ross Rounsevell, University of California Berkeley, US
Reconstitution of a dynamic actin-myosin II cortex on a giant vesicle scaffold
(short talk)

10:30 - 11:00

Coffee break

11:00 - 11:30

Patricia Bassereau - Insitut Curie, FR
Membrane nanotubes and intracellular traffic

11:30 - 11:45

Stephanie Miserey-Lenkei - Insitut Curie, FR
Rab and acto-myosin dependent fission of transport vesicles at the Golgi complex
(short talk)

11:45 - 12:00

Valeria Piazza - Georg-August-University Göttingen, DE
Multi-isotope Imaging mass spectrometry (MIMS) mapping of protein turnover in Hair cells reveals highly stable sterocilia
(short talk)

12:00 - 12:15

Eliza Morris - Harvard University, US
Transport in F-actin networks
(short talk)

12:15 - 12:30

David Richmond - University of California Berkeley, US
Forming vesicles with cellular features: new tools for cellular reconstitution
(short talk)

12:30

Lunch

14:00

Half-Day Excursion to Girona (free time)  

19:00

Dinner   

20:00 - 21:00

Forward Look Plenary Discussion

Session 6: Microtubules and Motors I

09:00 - 09:30

Anna Akhmanova - Erasmus Medical Centre Rotterdam, NL
Control of microtubule dynamics by End Binding proteins and their partners

09:30 - 10:00

Gero Steinberg - University of Exeter, UK
UK Microtubule organization and motors (kinesins) in fungal model systems

10:00 - 10:30

Carolyn Moores - Birbeck College, UK
Linking kinesin motor structure and function: small loops make a big difference

10:30 - 11:00

Coffee break  

11:00 - 11:30

Peter Rosenthal - NIMR, UK
EM Tomography of microtubules and Weibel Palade bodies   

11:30 - 12:00

Stan Burgess - University of Leeds, UK
EM Studies of Dynein

12:00 - 12:30

Takashi Ishikawa - Paul Scherrer Institute, CH
Molecular mechanism of flagellar/ciliary bending motion revealed by electron cryo-tomography

12:30

Lunch

Session 7: Microtubules and Motors II

15:30 - 16:00

Coffee break

16:00 - 16:30

Erika Hozbaur - University of Pennsylvania, US
Dual functions of dynein: vesicular motor and microtubule tether

16:30 - 16:45

Itushi Minoura - Riken Institute, JP
Dissecting the weak binding state of single-headed kinesin KIF1A using mutant microtubules
(short talk) 

16:45 - 17:00

Jeffrey Woodruff - University of California Berkeley, US
Mitotic spindle disassembly occurs via distinct subprocesses driven by the Anaphase-Promoting Complex Aurora B kinase and kinesin-8
(short talk) 

17:00 - 17:15

Johanna Roostalu - University of Heidelberg, DE
CIN8 is a kinesin that switches directionality in response to mechanical constraints
(short talk)

17:15 - 17:30

Isabelle Palacios - University of Cambridge, UK
Analysis of kinesin-1 function in vivo and in vitro
(short talk)

17:30 - 17:45

Leah Gheber - Ben-Gurion University of the Negev, IL
Regulation of Kinesin-5 motor protein function during mitosis
(short talk)

17:45 - 18:00

Ligon Lee - Rensselaer Polytechnic Institute, US
Microtubule reorganization and a switch in tubulin modification from detyrosination to acetylation as epithelial cells transition from 2D to 3D polarity
(short talk)

17:00 - 18:15

David Pastre - INSERM, FR
Polyamine: Microtubule interactions in the test tube and in cells
(short talk)

18:15 - 18:30

Yuyu Song - University of Illinois Chicago, US
Stabilisation of neuronal microtubules by polyamines and transglutaminase: its roles in brain function
(short talk)

19:00

Reception and Conference Dinner

08:00

Breakfast and Departure